Accutane (isotretinoin) can be prescribed for patients that have severe acne and want to get this condition under control. Never take this drug if you are pregnant, as Accutane has been classified as FDA pregnancy category X - harmful for the fetus and causing dangerous birth defects. Accutane will need to be taken regularly for you to benefit from the treatment. Make sure you take it twice a day with meals unless your health care provider recommended doing otherwise. It's important that you tell your doctor if you develop any serious side effects as a result of using Accutane - such as rash, diarrhea, vision problems, muscle weakness, fever, yellowing of the skin or eyes, worsening heartburn, dark colored urine, frequent urination, rectal bleeding, difficulty hearing, painful dryness of the eyes, joint or muscle pain, unusual thirst, and pounding heartbeat. However, serious side effects are unlikely. Accutane can sometimes cause just a few mild side effects - voice changes, nosebleeds, sweating, flushing, changes in skin color, bleeding gums, cold symptoms, peeling skin, hair loss, changes in the nails, unwanted hair growth, tiredness, and some other ones.